Starch-based controlled release matrix tablets: Impact of the type of starch

Different types of starches were used to prepare controlled release tablets loaded with diprophylline by direct compression. The impact the natural origin starch, potential chemical modifications (e.g., cross-linking phosphate or adipate, hydroxypropylation, acetylation different degrees, partial hydrolysis) and type pre-gelatinization process (laboratory scale ethanol oven drying versus industrial drum drying) on resulting drug kinetics studied. Texture analysis hydrogels created upon exposure medium, optical scanning electron microscopy as well X-ray powder diffraction measurements better understand observations. Also, a “quick test” using texture analyzer rapidly estimate capacity specific starch control rate was proposed. Two hydroxypropyl methylcellulose (HPMC K100 M LV) studied for reasons comparison. Interestingly, allowed detect differences in mechanical strength formed contact aqueous fluids, which correlated observed patterns from when measured USP III (“Bio’-Dis”) apparatus at 30 rpm. However, not very much affected investigated basket 75 This can be attributed lower stress experienced under these conditions. Furthermore, caution must paid studying types, are pre-gelatinized laboratory precipitation drying. obtained granules have significantly key properties compared drying, substantially patterns.